“While I am very supportive of adults receiving boosters as the data on benefit are clear, the risk-versus-benefit of booster vaccines for adolescents is less clear,” said David Boulware, an infectious-disease expert at the University of Minnesota Medical School. “Certainly, large-scale population data from Israel will be informative as to the safety of booster doses in adolescents. Overall, boosters in adolescents would be most important in households where there are immunocompromised adults or contact with elderly adults.”